CYP2C8 and breast cancer: Eltrombopag is a substrate of several drug-metabolizing enzymes, including cytochrome P450 (CYP) 1A2, CYP2C8, uridine diphosphate-glucuronosyltransferase (UGT) 1A1, and UGT1A3, and the agent is also a substrate of breast cancer resistance protein [27].