As many tumor antigens are self-antigens, for example, differentiation antigens like tyrosinase-related protein 2 (TRP-2), tumors can escape immune surveillance by recruiting nTregs or by inducing regulatory T cells (iTregs) from naïve or effector T cells through release of IL-10 or TGF-β1 [15, 17]. The gene discussed is TGFB1; the disease is neoplasm.