AD, Alzheimer’s Disease; Aβ, amyloid beta; APP, amyloid precursor protein; GFAP, glial fibrillary acidic protein; Iba1, ionized calcium binding adaptor molecule 1; PSD95, postsynaptic density protein 95; TNFα, tumor necrosis factor α. Here, AIF1 is linked to early-onset autosomal dominant Alzheimer disease.