TGFB1 and cancer: However, reconstitution of deficient TGFβ signaling can result in the direct activation of cell death and inhibition of metastasis thus indicating TGFβ is a metastatic suppressor in fully invasive carcinomas, thus indicating that at least in some cancer contexts the concept of enhancing TGFβ activity and/or the mechanisms by which TGFβ generates cell death could be of therapeutic value in highly progressed cancers.