CBS cells have been shown to be similar to the FETα engineered cells in that they have constitutive EGFR activation in addition to the attenuation of TGFβ tumor suppressor activity [38,49], thus providing a mechanism for retention of the capability of forming an invasive cancer at the primary site despite TGFβ activity generated by ectopic expression of the TGFβRII. Here, EGFR is linked to cancer.