Analysis identified 3 genes epigenetically deregulated in more than 50% of glioblastomas: MGMT, GATA6, and CASP8. To our knowledge, only MGMT has been previously widely described in glioblastomas, while the data on the epigenetic regulation of GATA6, CD81, DR4, and CASP8 in patient glioblastoma are scarce. This evidence concerns the gene TNFRSF10A and glioblastoma.