2). However, mRNA expression of procollagen type I, alpha 2, a gene in Table 2, did not significantly differ between the STR and CTL groups (data not shown). As a result, seven genes from Table 2 and Igf2 were decreased in the amygdala of CIS-induced depressed mice, and thus, we identified a total of eight genes as responders to CIS in the mouse amygdala. Here, IGF2 is linked to in situ carcinoma.