Using specialised oligonucleotide microarrays, we had identified aberrant promoter methylation of DKK2 and DKK3 and confirmed earlier findings for SFRP1, SFRP2 and SFRP4[16] on a limited number of primary CLL samples (unpublished data). The gene discussed is DKK2; the disease is B-cell chronic lymphocytic leukemia.