It has been demonstrated that the DcR3 gene is expressed at a low level in human embryo, lung, brain, liver, spleen, stomach, colon, lymph nodes and spinal cord, whereas it was expressed at a high level in cancers such as gastrointestinal cancer, hepatocellular carcinoma and pancreatic cancer [1,12]. Here, TNFRSF6B is linked to familial pancreatic carcinoma.