CFH and Alzheimer disease: One paper evaluated the presence of CFH and Aβ40 and Aβ42 peptides in the brains and retinas of several different transgenic AD mouse models (Tg2576, PSAPP, 3 × Tg-AD, and 5 × FAD) and found that there was a consistent inverse correlation between levels of Aβ and CFH in the retinas of these transgenics [130] suggesting that an environment promoting complement activation is a feature of AD retinas.