In addition to its role in adaptive gene expression and maintenance of cardiac function, MYOCD has also been implicated in the response of the adult heart to pathological stresses during severe hypertrophic remodeling [58, 89] and at end-stage HF due to dilated, ischemic, and cardiotoxic CM [56, 58, 90]. The gene discussed is MYOCD; the disease is hydrops fetalis.