SRF and hypertrophy: Cardiac hypertrophy is in part activated by multiple signalling molecules: the calcineurin phosphatase, the serine/threonine protein kinase AKT, the extracellular regulated MAP kinase (ERK), and several transcription factors like NFAT (nuclear factor of activated T-cells), GATA4, MEF2 (myocyte enhancer factor 2), SRF (serum response factor) and p-CREB (phosphorylated cAMPresponse element binding) acting on different target genes [9], [10].