To further clarify the role of TNF-α in the pathogenesis of EAN and to explore the potential of TNFR1 as a therapeutic target in GBS, we induced EAN in TNF-α KO mice and studied the effect of TNFR1 blockade with anti-TNFR1 antibodies on EAN. Here, TNFRSF1A is linked to Guillain-Barre syndrome.