TNFRSF1B and experimental autoimmune encephalomyelitis: However, in experimental autoimmune encephalomyelitis (EAE), an analogous experimental disorder of EAN in the central nervous system, TNFR1 KO mice were totally resistant to EAE, exhibiting reduced antigen-specific proliferative responses and Th1 cytokine production, whereas TNFR2 KO mice exhibited exacerbated EAE, enhanced Th1 cytokine production, and enhanced macrophage and T cell infiltration [27].