Contrary to the observations made by Meyerhardt and co-workers in 1997 [37], where they reported that neogenin was unaffected in a range of cancers including glioblastoma, the conclusions from Hanninen et al showed that the neogenin mRNA levels were lower in oligodendrogliomas, oligoastrocytomas, medulloblastomas and astrocytomas than in normal brain regions [38]. Here, NEO1 is linked to astrocytoma (excluding glioblastoma).