Since there was loss of neogenin in glioma tissues compared to their surrounding non-neoplastic tissues, sixty nine primary glioma cases (Table S2) from January, 2006 to January, 2011 in the Pathological Specimen Library of the First Clinical Hospital of Jilin University were collected for examination of relationship between neogenin expression and glioma malignancy. Here, NEO1 is linked to glioma.