In contrast, while males (n = 16, Table 5) had higher frequency of promoter methylation, they underwent remarkable down-regulation of neogenin (n = 11, p<0.01) than females (n = 5, p>0.05) in recurrent gliomas (Table 4) implying that men patients may recur easily and progress faster in later stage of glioma. The gene discussed is NEO1; the disease is glioma.