DYSF and autosomal recessive limb-girdle muscular dystrophy type 2B: Mutations in dysferlin have been shown to lead to a variety of muscle phenotypes that range from mild to severe, including the prominent Limb-Girdle Muscular Dystrophy type 2B [LGMD2B; OMIM 253601; [1]] and Miyoshi Myopathy (MM, OMIM 254130, [2]].