NFKB1 and cancer: The nuclear localization signals of NF-κB protein are exposed and its p65 subunit is phosphorylated, leading to nuclear translocation and transcriptional activation potential, and finally inducing the expression of a large number of target genes.[3], [4] Compelling evidence has been demonstrated that aberrant NF-κB regulation is associated with initiation and progression of various types of human cancer, including PCa, by regulating the expression of genes important for many steps of tumorigenesis and progression [2].