The smaller allele frequency of the CFB SNP (1.8% in our cases, 6.7% in the European ancestry 1000G individuals) compared to SNP frequencies in CFH and ARMS2/HTRA1 results in a reduced power to detect association and may explain why CFB SNP rs4151667 was not among those detected first by AMD GWAS. Here, CFB is linked to age-related macular degeneration.