Given that the reduced expression of genes at the DLK1-MEG3 and HOX loci is associated with sporadic pituitary tumors and parathyroid tumors, respectively [16], [17] (endocrine tumor types also found in the MEN1 syndrome), our data suggests a possible role for menin-dependent H3K4me3 at these genes in the initiation and progression of sporadic pancreatic neuroendocrine tumors. Here, MEG3 is linked to pancreatic neuroendocrine tumor.