Further investigations analyzing the regulation of menin targets (HOX and DLK1-MEG3 genes) during the initiation and progression of tumors found in MEN1 or MEN1-like sporadic endocrine tumors will be instrumental in correlating these events as biomarkers and/or causes of endocrine neoplasia. The gene discussed is DLK1; the disease is Neoplasm of the endocrine system.