The MEG3 and HOX loci, identified in this study to be regulated by menin-dependent H3K4me3, assumes significance given that genes within these loci have been implicated in MEN1-like tumors types: silencing of MEG3 in pituitary tumors and HOX genes in parathyroid tumors [16], [17] (Figure7B). Here, MEN1 is linked to pituitary tumor.