Taken together, down-regulation or over-expression of SENP1, c-Jun or AR appears to significantly inhibit Triptolide anti-PCa toxicity, indicating that down-regulation of SENP1, c-Jun or AR by Tritpolide is important for Tritplode activity, suggesting these proteins are key targets of Triptolide for its' anti-PCa effect. This evidence concerns the gene AR and posterior cortical atrophy.