We found that down-regulation of SENP1, c-Jun or AR expression suppress PCa cell viability, which consist with previous reports that SENP1, c-Jun and AR have pro-proliferation roles in PCa and further suggest that Triptolide anti-PCa effect could be through down-regulation of SENP1, c-Jun and AR expression. This evidence concerns the gene SENP1 and posterior cortical atrophy.