Since we observed that Triptolide suppressed SENP1 expression, enhanced cellular SUMOylation, inhibited AR and c-Jun expression and suppressed AR/c-Jun-mediated transcription, we asked whether Triptolide anti-PCa efficacy relies on SENP1, c-Jun or AR expression in LNCaP and PC-3 cells. This evidence concerns the gene JUN and posterior cortical atrophy.