Clearly, a significant population of early and late apoptosis (H1299: 7.22%; A549: 10.45%) was observed in cells with TRIM24 knockdown compared with scramble controls (H1299: 3.76%; A549: 8.43%), demonstrating that TRIM24 knockdown results in apoptosis of the lung cancer cells, especially in H1299 cells which have high endogenous TRIM24 expression. This evidence concerns the gene TRIM24 and lung cancer.