THRSP and cyclic hematopoiesis: Furthermore, the mRNA levels of ME (0.15±0.10 vs. 1±0.04; P = 0.0001) and Spot14 (0.30±0.10 vs. 1±0.02; P = 0.0001), two genes positively regulated by TH [1], were also markedly reduced in the CH group.