Although CH rats were euthyroid on PND80 (i.e., the time when the comparative gene expression was performed), they showed changes in liver gene expression in comparison with age-matched INTACT rats (see above) that involved previously characterized T3 (e.g., ME) or GH (e.g.SOCS2, CIS, IGF-I, CYP2C11, INSIG-1, and IGFBP-3) regulated genes. The gene discussed is INSIG1; the disease is cyclic hematopoiesis.