Subtle changes in hepatic IGF-I (Fig. 2A) and IGFBP-3 (Fig. 2B) mRNA levels together with increased levels of IGFBP-2 (Fig. 2C), a gene that is a marker of delayed development or hypothyroidism in rats [4], [49], were also shown on PND80. The gene discussed is IGF1; the disease is hypothyroidism.