A mean of 65.6%±7 tTReg cells expressed surface ICOS (n = 5) compared with 6.6%±1.5 nTReg cells from age-matched controls (n = 14) and 8.1%±1.3 nTReg cells from patients with MM (n = 10; p<0.0001; Figure 5D). This evidence concerns the gene ICOS and Miyoshi myopathy.