Next to determine if this was a MM-specific effect, we co-cultured CD4+CD25- T-cells with a selection of HMCL (U266, JJN3, JIM3 & KMS11), a myeloid-derived cell line (K562) and non-heamatopoietic cell lines (Mel888 & HeLa). This evidence concerns the gene CD4 and Miyoshi myopathy.