CD4 and neoplasm: The inhibition of tumour-generated CD4+ TReg cells through abolition of cell-to-cell contact was associated with a reduction in the production of IL-10 (69.8±33.6 pg/ml vs 6.3±0.01 pg/ml, n = 3, p = 0.079) and IFNγ (12154±4174 pg/ml vs 0.04±0.01 pg/ml, n = 3, p<0.001).