IL10 and neoplasm: This model of induction tTReg cell however, does not account for chronic antigen stimulation by the tumour-bearing host, nor does it this culture system take allowances of the effects of immunomoduatory drugs such as steroids and IMiDs (Thalidomide, Lenalidomide, Pomalidomide) which may account for differences in ICOS expression between tTReg cell and TReg cells from MM patients, a significant level of IL-10 is produced though this contributes minimally to the generation of tTReg cells (as evidenced by lack of inhibition through monoclonal antibody blockade).