Staining brain tissue sections derived from 130-day old G93A-SOD1 mice by ALS-IgG or healthy control IgG, and staining for CD16 on microglia and neurons supported our hypothesis for neuron loss through ADCC that can be mediated by IgG with the A2BG2 glycan. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.