FCGR3A and amyotrophic lateral sclerosis: To investigate whether the elevated amounts of A2BG2 glycan enhance co-localization of ALS-IgG with CD16 and with microglia, pools of IgG purified from healthy candidates or from ALS patients, with and without the Fc N-glycans were used on brain and spinal cord tissue sections of mSOD1 mice and wild-type littermates.