Intact ALS-IgG, with the Fc glycans, were significantly found in 130-day old mSOD1 brain and spinal cord tissues as opposed to lower localization of PNGase-F-treated ALS-IgG and of IgG of healthy candidates in mSOD1-matched tissues (Fig. 3A, B). The gene discussed is NGLY1; the disease is amyotrophic lateral sclerosis.