Taken together, our results related to the increase in amount of IgG-A2BG2 glycoform in ALS sera, the CD16 over-expression in tissue sections of G93A-SOD1 mouse brains and spinal cords, and the co-localization of ALS-IgG with CD16 and brain microglia, suggest that N-glycans of ALS-IgG may be involved in ADCC reactions. This evidence concerns the gene FCGR3A and amyotrophic lateral sclerosis.