Consistent with increased BrCa1 in obesity, increased P-ACC levels were shown in both SC (1.9-fold, p = 0.007; Fig. 1b) and OM (2.1-fold, p = 0.010; Fig. 1d) adipose tissue from obese subjects (Table 1), and in SC when compared to OM fat depots (1.7-fold, p = 0.001; Fig. S1b). Here, BRCA1 is linked to obesity due to melanocortin 4 receptor deficiency.