TSC22D3 and multiple sclerosis: Recently, a small peptide mimic of GILZ, GILZ-P, has been developed by conceptually integrating the mechanism of action glucocorticoids and the knowledge derived from the structural analysis of GILZ and its interaction with the p65 subunit of NF-κB. Treatment with GILZ-P suppressed T-cell activation and inflammation in a mouse model for multiple sclerosis [117].