In present study, we confirmed that SNP rs6887695 in the gene IL-12b was associated with SLE in the Mainland Chinese Han population, which replicated the findings from a GWAS study in Caucasian population [19], while in a previous study, two SNPs located in the promoter and 3′UTR region of IL-12b gene, respectively, exhibited no association with the susceptibility of SLE in Spanish population [25]. Here, IL12B is linked to systemic lupus erythematosus.