VEGFA and neoplasm: Indeed, in skin carcinogenesis model, TGFβ1 increases the intracellular ROS level in stromal fibroblasts, which initiated the MMT and concomitant changes of gene expression, leading to the secretion of Hepatocyte Growth Factor, Interleukine-6, and Vascular Endothelial Growth Factor that result in proinvasive signals for migration of tumour cells [47].