Very interestingly, the p62-positive aggregates observed in hepatocytes and neurons of liver- and brain-specific Atg7 deficient mice, respectively, as well as in human hepatocellular carcinoma cells, are completely dispersed by the additional loss of p62 strongly implicating involvement of p62 in the formation of disease-related inclusion bodies [104, 152]. This evidence concerns the gene SQSTM1 and hepatocellular carcinoma.