For this particular paper, we will focus on the following topics: (1) molecular alterations of AKT in human cancers, (2) isoform-specific role of AKT in human cancers, (3) tobacco carcinogen-induced AKT activation, (4) in vivo role of AKT in human cancers, and (5) regulation of AKT by interacting proteins. This evidence concerns the gene AKT1 and cancer.