Classical risk factors, such as lipids and glucose, have been well-established in coronary artery disease (CAD), while four additional markers have sufficient evidence of clinical utility to be recommended for regular clinical use: (1) cardiac troponin I and T; (2) B-type natriuretic peptides; (3) D-dimer; and (4) C-reactive protein (CRP) [1]. Here, TNNI3 is linked to coronary artery disorder.