Treatment of influenza-infected mice with celecoxib, a selective COX-2 inhibitor, did not significantly affect viral titers or disease severity, although treatment did suppress production in the lung of the proinflammatory cytokines tumor necrosis factor- (TNF-) α, IL-6 and granulocyte-colony stimulating factor (G-CSF) [98]. The gene discussed is CSF3; the disease is influenza.