WFS1 and diabetes mellitus: In the 111 candidate genes, we also identified novel (not present in 50 in-house exomes, 340 healthy controls or 1000 Genomes) variants in potentially interesting genes implicated in susceptibility to diabetes, albeit thus far not in an autosomal dominant mode of inheritance: ARAP1, GLIS3, MADD, NOTCH2 and WFS1 (Table 4).