However, siRNA-mediated knock-down of CHOP showed that it plays no role in 11β-HSD1 expression in fully differentiated 3T3-L1 adipocytes, although we cannot rule out that increased CHOP levels may contribute to the down-regulation of 11β-HSD1 in adipose tissue with HF diet. The gene discussed is DDIT3; the disease is hydrops fetalis.