Here we show that the KRAS-variant, a functional germline miRNA-binding disrupting mutation that has previously been shown to be associated with ovarian cancer, especially in HBOC families [9], as well as with premenopausal triple negative breast cancer [10], is also significantly enriched in women who develop both breast and ovarian cancer with uninformative BRCA sequencing results (Table 5). Here, KRAS is linked to triple-negative breast carcinoma.