The finding that the KRAS-variant is associated with uninformative women with double primary cancer is important, as it further confirms that 1) the KRAS-variant is associated with uninformative HBOC families, 2) appropriate intervention for patients with the KRAS-variant who develop breast cancer may allow prevention of future ovarian cancer and 3) women with cancer that have the KRAS-variant may benefit from screening to detect additional cancer development at its earliest stages. The gene discussed is KRAS; the disease is breast carcinoma.