Conversely, Crebbp+/− mice, with a mutant allele of the histone acetylase CREB-binding protein, displayed a phenotypes similar to that of Sik3−/− mice, e.g., lipodystrophy, increased glucose tolerance, resistance to diet-induced obesity, and hyperadiponectinemia [55], suggesting that SIK3 may regulate energy balance by regulating acetylation states. This evidence concerns the gene SIK3 and obesity due to melanocortin 4 receptor deficiency.