As shown in Table S1, the resistance to diet-induced obesity in Sik3−/− mice might be explained by the low levels of lipogenic mRNA, e.g., Fasn and Scd1. Amelioration of hepatic injury in Sik3−/− mice by the high-fat diet was probably due to the down-regulation of cholesterol (HmgCoAr) and BA (Cyp7a) synthesis. Here, SIK3 is linked to obesity due to melanocortin 4 receptor deficiency.