Further our results demonstrate that combinations of GTPs and SFN induced the release of co-repressor complexes to the demethylated ERα promoter and the disruption of transcriptional repressor multi-molecular complex, HDAC1/DNMT1/SUV39H1, is actively associated with ERα transcriptional activation in ERα-negative breast cancer cells [8]. Here, SUV39H1 is linked to breast cancer.