NFKB1 and colitis: Recent studies indicated that the anti-inflammatory effect of 5-ASA is mediated by the activation of PPARγ [9]–[11], a nuclear receptor whose agonists can suppress or delay inflammation effectively by inhibiting multiple steps in NF-κB and AP-1 signaling pathways [7], [8] and attenuating the production of nitric oxide (iNOS) and macrophage-derived cytokines such as TNFα, IL-1 and IL-6 in mouse models of colitis [16], .