Previous studies have reported that TRAIL and its functional receptors: DR4 and DR5 are up-regulated in the liver of HCV-infected patients [18], [19] and that the expression levels of DR4 and DR5 are elevated in some cases of HCV-related hepatocellular carcinoma (HCC) [20]. The gene discussed is TNFRSF10B; the disease is hepatocellular carcinoma.