Lan et al. (2008) reported that DR4 and DR5 are not up-regulated in JFH-1 infected Huh7.5 cells, whereas Zhu et al. (2007) reported that the expression of DR4 and DR5 is elevated in a JFH-1 infected hepatoma cell line, named by LH86 [4], [23]. Here, TNFRSF10B is linked to hepatocellular carcinoma.