MKI67 and neoplasm: The principal outcome of this quality control effort is that interobserver variability of MIB-1 labeling index in breast carcinomas is (i) more problematic than we had expected, (ii) not easily explained by obvious confounders such as the immunostaining technique and the selection of the tumor area, (iii) not reduced by (meticulous) counting versus (rapid) eyeballing, and (iv) not improved by efforts to standardize what exactly are MIB-1 positive nuclei and where and how to count them.