IGF2 and metastatic malignant neoplasm in the lymph nodes: A significant relationship was observed, however, among breast cancer with different histological grade, with or without lymph node metastasis and with or without oestrogen receptor positivity in the expression of IGF-2, and the difference was statistically significant ( = 14.17, 5.10, 7.60 respectively; P values 0.0002, 0.0239, 0.0058 respectively).