In benign breast lesions, breast cancer and tumor-adjacent tissue, IGF-2 was mainly expressed in the cytoplasm, but in different tissues the expression was different (p<0.05).In 63 cases of breast invasive ductal cancer, 26 cases were positive for IGF-2.While 7 of 59 cases of breast cancer-adjacent tissue, the expression of IGF -2 was positive, but most of them were weakly positive. This evidence concerns the gene IGF2 and breast cancer.