As PI3K/Akt pathway is an important player in the regulation of lipid metabolism, and previous evidence suggests that SREBP-2 is activated by PI3K/Akt in diabetes, cancer and viral infections [24], we proceeded to investigate whether PI3K/Akt pathway activates SREBP-2 in osteoarthritic chondrocytes. The gene discussed is SREBF2; the disease is diabetes mellitus.