SREBF2 and atherosclerosis: More specifically, SNP 1784G >C in SREBP-2 gene, which play a key role in cholesterol homeostasis, results in substitution of a glucine by an alanine at amino acid 595 of the SREBP-2 protein (G595A) and has been associated with intima-media thickness (IMT), a marker of atherosclerosis, total cholesterol levels in hypercholesterolaemic subjects and elevated plasma lipids levels [22], [23].