Cytokines identifies as predictors included IL-12(p70), IL-1β, IL-5, IL-7, LIF, and TNF-β When each biomarker was evaluated individually, wide deviation limited predictive ability (Figure 3B, and figure S2C), however a use of a multiplex profile of biomarkers predicted imminent onset of RA (Table 2 and Figure 3A). Here, IL1B is linked to rheumatoid arthritis.