The same age-associated distribution of ATRX mutation was identified across the entire GBM cohort including both DIPGs and supratentorial GBM [mean age 16.91 (±2.11) vs. 8.00 (±0.69) years, p < 0.0001 for ATRX mutant versus wild-type cases; Fig. 2c). This evidence concerns the gene ATRX and glioblastoma.