Notably, the presence of ATRX mutation significantly overlapped with TP53 mutations in GBM (p = 0.01) regardless of the location within the brain and with G34V/R mutants in supratentorial GBM (p < 0.0001), and were age-dependent as they mainly occurred in older children (p < 0.0001). Here, ATRX is linked to glioblastoma.