Our present study showed obvious TRAF6 expression in intimal and subintimal CD68+ cells, CD68+ cell desity in the high TRAF6 expression group of RA synovium was significantly higher than that in the low TRAF6 expression group, and significant correlation was found between synovial TRAF6 expression and CD68+ cell density. The gene discussed is CD68; the disease is rheumatoid arthritis.