Here we showed that the cell density of subintimal CD68+ cells, CD3+ cells and CD34+ cells in the high TRAF6 expression group of RA synovium were significantly higher than that in the low TRAF6 expression group, and synovial TRAF6 expression was correlated significantly with cell density of subintimal mononuclear inflammatory cells, including CD68+ cells, CD3+ cells, CD38+ cells, CD20+ cells and CD79a+ cells. The gene discussed is TRAF6; the disease is rheumatoid arthritis.