Significantly enhanced synovial expression of TRAF6 was detected from RA patients compared to those from OA or Orth.A patients (2.53 ± 0.94 vs 0.72 ± 0.44 and 0.71 ± 0.49, P < 0.0001) (Figure 3). Here, TRAF6 is linked to rheumatoid arthritis.