made from a retrospective analysis of 1990 to 1992 of parameters influencing survival of HCC patients and validated by authors and others groups in several prospective studies, CLIP score combines parameters predictive of survival: severity of liver disease (Child-Pugh score Tables 2 and 3), and tumor characteristics as tumor morphology, AFP rate, existence of portal vein thrombosis and classifies patients with HCC into six groups. This evidence concerns the gene AFP and hepatocellular carcinoma.