CXCL12 and neoplasm: The significant increase in chemotaxis induced by IL-1β in MCF-7A3 cells towards chemokine CXCL12, known to be secreted by cells in target organs of invasive mammary cells and considered a marker of tumor progression to malignancy [33], could be directly correlated with the increase of CXCR4 levels and the higher stability of IL-1RI that was registered in these cells after exposure to IL-1β.