FADD and neoplasm: Previous studies showed that blocking integrin-αvβ3 via RGD peptides induces cell death in human endothelial cells through activation of caspase-3, -8 and -9, FADD (Fas-Associated protein with Death Domain), tumor necrosis factor-α and TRAIL (TNF related apoptosis inducing ligand) pathways and is correlated to the down-regulation of FAK (focal adhesion kinase) expression in tumor cells [39], [40].