The protection of renal function was not observed in the TLR2−/− or TLR4−/− mice when we analyzed the biochemical parameters, but there was a significant improvement in ATN in these mice compared with WT by renal histology, suggesting that TLR2 and TLR4 are required during polymicrobial sepsis. The gene discussed is TLR2; the disease is oculocutaneous albinism type 1.