TLR4 and Sepsis: We observed that sepsis induced an increase in vascular permeability in the kidneys of the WT mice (4.20±0.33 μg/mg); however, the TLR2−/− (2.99±0.18 μg/mg), TLR4−/− (2.31±0.31 μg/mg, p<0.01) and MyD88−/− mice (2.37±0.22 μg/mg, p<0.01) had lower vascular permeability indexes compared with the WT septic mice, underscoring the renal protection already observed (Figure 6).