Other studies have also shown secretoneurin to protect endothelial cells from apoptosis through Erk1/2 signaling [27], [28], and to attenuate neuronal cell death after ischemia by induction of the Jak/Stat pathway [13], providing support for secretoneurin as a protective factor in the subacute phase of tissue ischemia. The gene discussed is MAPK3; the disease is ischemia.