As evaluated by receiver operating analysis, circulating levels of SgII were more closely regulated in HF than both CgA (AUC = 0.84 for SgII vs. AUC = 0.57 for CgA, p = 0.001) and CgB levels (AUC = 0.68 for CgB, p = 0.03 vs. SgII). This evidence concerns the gene CGA and hydrops fetalis.