Recent evidence for the involvements of PPARα signaling in anti-angiogenesis properties resulting from inhibition of either vascular NADP oxidase 1 [63] or epoxidase which takes place in arachidonate metabolism [64] strengthens further the interest of PPARα ligands in disrupting tumor-host stroma symbiosis through antiangiogenic (and anti-inflammatory) mechanisms. This evidence concerns the gene PPARA and neoplasm.