Additionally, modulation of the Wnt/β-catenin signalling pathway may also account for some PPARγ mediated beneficial effects in AD since recent findings show that PPARγ mediated protection of hippocampal neurons against Aβ-induced toxicity directly correlates with β-catenin levels, inhibition of GSK 3β activity and increased levels of Wnt-target genes [35,75]. The gene discussed is PPARG; the disease is Alzheimer disease.